Methyl bromoacetate → HCID 17795969, compound

HRID 2187072Notes

Reaction equation

Br[CH2:2][C:3]([O:5][CH3:6])=[O:4].[O:7]=[C:8]1[N:17]([CH2:18][CH2:19][CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][CH:25]([O:28][CH:29]([C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)[C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH2:24][CH2:23]2)[C:16](=[O:42])[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[NH:9]1>>[O:7]=[C:8]1[N:17]([CH2:18][CH2:19][CH2:20][CH2:21][N:22]2[CH2:23][CH2:24][CH:25]([O:28][CH:29]([C:36]3[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=3)[C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=3)[CH2:26][CH2:27]2)[C:16](=[O:42])[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]1[CH2:2][C:3]([O:5][CH3:6])=[O:4]

Participants

Reactant 2

HCID 60984Methyl bromoacetate

HCID 22449569HCID 22449569, compound

Product 1

HCID 17795969HCID 17795969, compoundYield 44%

Procedure

Using the method similar to that in Example 57 and methyl bromoacetate instead of 1-bromo-2-phenylethane and starting from 2,4-dioxo-3-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline (1.52 g) obtained in Example 80, the title compound (760 mg, 44%) was obtained as an oil.

Sources & evidence

ORD record: ord-5116220ea06f4dd2badaad956194050e
Source dataset: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06407116B1

Reaction notes

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