Dimethylformamide → HCID 11024302, compound

HRID 2187340Notes

Reaction equation

HRID 2187340 reaction equation
[C:1]([NH:5][S:6]([C:9]1[CH:14]=[CH:13][C:12](N)=[CH:11][C:10]=1[C:16]([O:18][CH3:19])=[O:17])(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2].CO[CH:22](OC)[N:23]([CH3:25])[CH3:24].C[N:29](C)C=O>>[C:1]([NH:5][S:6]([C:9]1[CH:14]=[C:13]([N:29]=[CH:22][N:23]([CH3:25])[CH3:24])[CH:12]=[CH:11][C:10]=1[C:16]([O:18][CH3:19])=[O:17])(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 78373Dimethylformamide dimethyl acetalHCID 17909971HCID 17909971, compound

Product 1

HCID 11024302HCID 11024302, compound

Conditions

Temperature
55 °C

Procedure

A mixture of 3.15 g of N-tert-butyl4-amino-2-methoxycarbonylbenzenesulfonamide, 2.2 ml of N,N-dimethylformamide dimethyl acetal and 60 ml of N,N-dimethylformamide is stirred at 50-60° C. until the reaction has ended. The volatile components are then distilled off under reduced pressure. The residue is washed with a little diisopropyl ether. This yields 3.52 g of the desired amidine derivative.

Workup

  1. distillationThe volatile components are then distilled off under reduced pressure
  2. washThe residue is washed with a little diisopropyl ether

Sources & evidence

ORD record
ord-d914e75fa9e543d7a46f1616e7c0d58e
Source dataset
uspto-grants-2002_06
Patent number
US06410482B1

Reaction notes

Loading…