Chloro-N,N-dimethylformiminium chloride → HCID 18475304, compound

HRID 2187344Notes

Reaction equation

HRID 2187344 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([NH:11][C:12]([NH:14][S:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[NH2:24])(=[O:17])=[O:16])=[O:13])[N:4]=1.[Cl-].Cl[CH:27]=[N+:28]([CH3:30])[CH3:29]>CN(C=O)C>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([NH:11][C:12]([NH:14][S:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[N:24]=[CH:27][N:28]([CH3:30])[CH3:29])(=[O:17])=[O:16])=[O:13])[N:4]=1

Participants

4

Reactant 2

HCID 77311Chloro-N,N-dimethylformiminium chlorideHCID 13138217HCID 13138217, compound

Product 1

HCID 18475304HCID 18475304, compoundYield 30.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 0.80 g of N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-aminobenzenesulfonamide, 0.29 g of [chloromethylene]dimethylammonium chloride and 8 ml of DMF is stirred at room temperature until the reaction has ended. The volatile components are distilled off under reduced pressure and the residue is washed with water and methyl acetate, affording 0.28 g of the desired product. Melting point: 209-210° C. (decomp.)

Workup

  1. distillationThe volatile components are distilled off under reduced pressure
  2. washthe residue is washed with water and methyl acetate

Sources & evidence

ORD record
ord-284b8cb152734a68abb754d04dc6e0fd
Source dataset
uspto-grants-2002_06
Patent number
US06410482B1

Reaction notes

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