Hydrochloric Acid → HCID 18475684, compound

HRID 2187360Notes

Reaction equation

HRID 2187360 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=O)[C:5]2=[O:12].[OH-:13].[K+].[C:15]([OH:20])(=[O:19])[C:16]([CH3:18])=O.Cl>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]=[C:6]([C:5]([OH:12])=[O:13])[CH:18]=[C:16]2[C:15]([OH:20])=[O:19]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 1060Pyruvic AcidHCID 14797Potassium HydroxideHCID 2365665-Fluoroisatin

Product 1

HCID 18475684HCID 18475684, compoundYield 104.5%

Procedure

5-Fluoroisatin (9.74 g) was added to a hot solution of 33% potassium hydroxide (29.1 g in 85 ml water). Pyruvic acid (9.25 g) was added, the mixture stirred at room temperature for 1 h and boiled for 1 h. The mixture was cooled to room temperature and acidified with c.HCl. After refridgerating overnight, the precipitated material was collected by filtration and dried in vacuo at 50° C. to give the title compound (14.5 g).

Workup

  1. waitboiled for 1 h
  2. temperatureThe mixture was cooled to room temperature
  3. waitAfter refridgerating overnight
  4. filtrationthe precipitated material was collected by filtration
  5. customdried in vacuo at 50° C.

Sources & evidence

ORD record
ord-b86d560b33ba4f0dadbffcdc2eefb71d
Source dataset
uspto-grants-2002_06
Patent number
US06410529B1

Reaction notes

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