Triethylamine → HCID 18475662, compound

HRID 2187363Notes

Reaction equation

HRID 2187363 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[NH2:6][C:7]1[CH:8]=[C:9]([NH:13][C:14]([NH:16][C:17]2[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[N:20]=[CH:19][CH:18]=2)=[O:15])[CH:10]=[CH:11][CH:12]=1.C(N(CC)CC)C>ClCCl>[N:20]1[C:21]2[C:26](=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:17]([NH:16][C:14](=[O:15])[NH:13][C:9]2[CH:8]=[C:7]([NH:6][S:2]([CH3:1])(=[O:4])=[O:3])[CH:12]=[CH:11][CH:10]=2)=[CH:18][CH:19]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 18475631HCID 18475631, compound

Product 1

HCID 18475662HCID 18475662, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Methanesulphonyl chloride (27 ul) was added to 1-(3-aminophenyl)-3-quinolin-4-ylurea (0.08 g) in dichloromethane (25 ml) containing triethylamine (48 ul) and stirred for 16 h. The precipitate that formed was separated by filtration, washed with tetrahydrofuran and diethyl ether and dried to give the title compound (0.081 g).

Workup

  1. customThe precipitate that formed
  2. customwas separated by filtration
  3. washwashed with tetrahydrofuran and diethyl ether
  4. customdried

Sources & evidence

ORD record
ord-24495b2207bf4a56aa0f5e27da2d30c9
Source dataset
uspto-grants-2002_06
Patent number
US06410529B1

Reaction notes

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