反应详情

To a stirred solution of 2-4 (422 mg, 1.92 mmol) in TBF was added 5.75 mL of 9-BBN (0.5 M/THF). After 18 hours, a slurry of NaBO3 (2.35 g) and NaHCO3 (2.42 g) in H2O (10 mL) was added and the mixture stirred vigorously for 1 hour. The mixture was extracted with CHCl3, washed with brine, and dried over MgSO4. Following evaporative removal of the solvent, the residue was chromatographed (silica gel, 3% EtOH/EtOAc) to give 2-5 as a clear oil.

1. extractionThe mixture was extracted with CHCl3
2. washwashed with brine
3. dry with materialdried over MgSO4
4. customremoval of the solvent
5. customthe residue was chromatographed (silica gel, 3% EtOH/EtOAc)