反应详情

HCl was bubbled into a n-butanol solution (200 mL) of pent4-ynoic acid 14-3 (10 g, 102 mmol) for ten minutes. The solution stirred overnight at room temperature. The solvent was removed in vacuo providing the crude ester 14-4 as a yellow liquid in quantitative yield.

1. customThe solvent was removed in vacuo