MAGNESIUM SILICATE (synthetic) → HCID 21864738, compound

HRID 2187557Notes

Reaction equation

HRID 2187557 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]1[CH2:12][CH:5]2C=C1.C[N+]1([O-])[CH2:19][CH2:18][O:17]CC1.[O-:21][Si]([O-])=O.[Mg+2].OS([O-])=O.[Na+]>CC(C)=O.O.O=[Os](=O)(=O)=O>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]1[CH2:12][CH:5]2[CH:18]([OH:17])[CH:19]1[OH:21]

Participants

8

Reactant 4

HCID 61680MAGNESIUM SILICATE (synthetic)HCID 82029Methyl morpholine oxideHCID 1435636-Fluoro-1,4-dihydro-1,4-methanonaphthaleneHCID 23665763Sodium Bisulfite

Product 1

HCID 21864738HCID 21864738, compound

Reagents, catalysts & solvents 3

HCID 30318Osmium TetroxideCatalystHCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

6-Fluoro-1,4-dihydro-1,4-methano-naphthalene (680 mg, 4.22 mmol) and N-methyl morpholine N-oxide (599 mg, 4.43 mmol) were stirred in acetone (50 mL) and H2O (5 mL). To this was added a solution of OsO4 (0.2 mL, 2.5% wt. solution in t-BuOH, 0.02 mmol). After 72 hours, florisil (5 g) and saturated aqueous NaHSO3 solution (3 mL) were added and stirred for 1 hour. The florisil was filtered and the filtrate concentrated to produce a crystalline product which was triturated with acetone and filtered (524 mg, 64%) 1H NMR (400 MHz. CDCl3) δ7.10(dd, J=8.0,5.0 Hz, 1H), 6.90 (dd, J=8.0,2.3 Hz, 1H), 6.75 (ddd, J=8.0,8.0,2.3 Hz, 1H), 3.79 (s, 2H), 3.18 (d, J=1.5 Hz, 2H), 2.22 (d, J=10.0 Hz, 1H), 1.92 (dd, J=10.0,1.5 Hz, 1H). GCMS m/e 194 (M+).

Workup

  1. filtrationThe florisil was filtered
  2. concentrationthe filtrate concentrated
  3. customto produce a crystalline product which
  4. customwas triturated with acetone
  5. filtrationfiltered (524 mg, 64%) 1H NMR (400 MHz. CDCl3) δ7.10(dd, J=8.0,5.0 Hz, 1H), 6.90 (dd, J=8.0,2.3 Hz, 1H), 6.75 (ddd, J=8.0,8.0,2.3 Hz, 1H), 3.79 (s, 2H), 3.18 (d, J=1.5 Hz, 2H), 2.22 (d, J=10.0 Hz, 1H), 1.92 (dd, J=10.0,1.5 Hz, 1H)

Sources & evidence

ORD record
ord-d8d33ea96776494baeb770615dfc929e
Source dataset
uspto-grants-2002_06
Patent number
US06410550B1

Reaction notes

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