Triphenylphosphine → HCID 18476349, compound

HRID 2187638Notes

Reaction equation

HRID 2187638 reaction equation
[Br:1][CH2:2][C:3]1[S:7][C:6]2[CH:8]=[CH:9][C:10]([Cl:12])=[CH:11][C:5]=2[CH:4]=1.[C:13]1([P:19]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C1(C)C(C)=CC=CC=1>[Br-:1].[Cl:12][C:10]1[CH:9]=[CH:8][C:6]2[S:7][C:3]([CH2:2][P+:19]([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)=[CH:4][C:5]=2[CH:11]=1

Participants

4

Reactant 2

HCID 11776TriphenylphosphineHCID 136426062-(Bromomethyl)-5-chloro-1-benzothiophene

Product 1

HCID 18476349HCID 18476349, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Conditions

Temperature
140 °C

Procedure

A mixture of 2.50 g (9.56 mmol) 2-bromomethyl-5-chlorobenzo[b]thiophene and 2.51 g (9.57 mmol) triphenylphosphine in 50 ml xylene was heated at 140° C. After 3 h the reaction mixture was cooled to room temperature, and the phosphonium salt was filtered off, washed with xylene and tert.-butylmethylether, successively, and dried in vacuo.

Workup

  1. temperatureAfter 3 h the reaction mixture was cooled to room temperature
  2. filtrationthe phosphonium salt was filtered off
  3. washwashed with xylene and tert.-butylmethylether
  4. customsuccessively, and dried in vacuo

Sources & evidence

ORD record
ord-afa661bf2ed54484b6cccf7a7a1867bc
Source dataset
uspto-grants-2002_06
Patent number
US06410562B1

Reaction notes

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