Hydrochloric Acid → HCID 178499561, compound

HRID 2187885Notes

Reaction equation

HRID 2187885 reaction equation
[ClH:1].[NH:2]1[CH:6]=[C:5]([CH2:7][C:8]([OH:10])=[O:9])[N:4]=[CH:3]1.Cl.[CH:12](OC)(OC)OC>CO>[ClH:1].[NH:2]1[CH:6]=[C:5]([CH2:7][C:8]([O:10][CH3:12])=[O:9])[N:4]=[CH:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 9005Trimethyl orthoformateHCID 178479752HCID 178479752, compound

Product 1

HCID 178499561HCID 178499561, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 4-imidazoleacetic acid hydrochloride (4.00 g, 24.6 mmol) in MeOH (100 mL) was saturated with HCl (g). Trimethyl orthoformate (10 mL, 91 mmol) was added and the mixture was stood at ambient temperature for 18 hrs, then concentrated to dryness in vacuo to afford the titled ester as a white solid.

Workup

  1. concentrationconcentrated to dryness in vacuo

Sources & evidence

ORD record
ord-9745553a4c664f7c8c6c9f1b51056f52
Source dataset
uspto-grants-2002_06
Patent number
US06410534B1

Reaction notes

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