Hydrochloric Acid → HCID 69779597, compound

HRID 2187889Notes

Reaction equation

HRID 2187889 reaction equation
C(OC([NH:8][C@H:9]([CH3:31])[C:10]([N:12]([C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([O:24]COCCOC)[CH:22]=2)[CH:17]=[CH:16][CH:15]=1)[CH3:13])=[O:11])=O)(C)(C)C.[ClH:32]>CCOC(C)=O>[ClH:32].[NH2:8][C@H:9]([CH3:31])[C:10]([N:12]([C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([OH:24])[CH:22]=2)[CH:17]=[CH:16][CH:15]=1)[CH3:13])=[O:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69785992HCID 69785992, compound

Product 1

HCID 69779597HCID 69779597, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of (R)-2-(tert-butoxycarbonylamino)-N-{7-[(2-methoxyethoxy)methoxy]naphthalen-1-yl}-N-methylpropionamide, as described above in Step C, (255 mg, 0.59 mmol) in EtOAc (10 mL) at ambient temperature was saturated with HCl (g). After 1 hr, the mixture was concentrated in vacuo to yield the titled product as a pale solid.

Workup

  1. concentrationthe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-c3579ca23f414b9fae9d53652b9e618c
Source dataset
uspto-grants-2002_06
Patent number
US06410534B1

Reaction notes

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