Sodium Carbonate → HCID 67287841, compound

HRID 218820Notes

Reaction equation

HRID 218820 reaction equation
I[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[OH:10].[Si:11]([C:18]#[C:19][CH2:20][O:21][Si:22]([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23])([C:14]([CH3:17])([CH3:16])[CH3:15])([CH3:13])[CH3:12].[Cl-].[Li+].C(=O)([O-])[O-].[Na+].[Na+]>CN(C)C=O.C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[Si:11]([CH:18]1[C:19](=[CH:20][O:21][Si:22]([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:23])[CH3:24])[C:2]2[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=2[O:10]1)([C:14]([CH3:17])([CH3:16])[CH3:15])([CH3:13])[CH3:12]

Participants

7

Reactant 4

HCID 10340Sodium CarbonateHCID 433294Lithium ChlorideHCID 10968062HCID 10968062, compoundHCID 114140152-Iodo-5-methoxyphenol

Product 1

HCID 67287841HCID 67287841, compoundYield 87%

Reagents, catalysts & solvents 2

HCID 167845palladium(II) acetateCatalystHCID 6228DimethylformamideSolvent

Procedure

A suspension of 2-iodo-5-methoxyphenol (1.1 g, 4.41 mmol), 1-(tert-butyldimethylsilyl) -3-(tert-butyldimethylsilyloxy)propyne (1.5 g, 5.28 mmol), lithium chloride (189 mg, 4.45 mmol) and sodium carbonate (2.34 g, 22.08 mmol) in dry dimethylformamide (5 mL) at 100° C. was deoxygenated 4 times by evacuation and backfilling with nitrogen. Palladium acetate (135 mg, 0.60 mmol) was added and the reaction vessel was degassed twice with nitrogen. The reaction mixture was then stirred at this temperature for 4 hours (monitored by tlc) and the solvent was removed by distillation under vacuum. The residue was dissolved in ethyl acetate (75 mL), stirred well, filtered and treated with triethylamine (5 mL). The solution was concentrated onto silica gel (10 g) and purified by flash chromatography (silica gel, eluent=hexane/diethyl ether/triethylamine; 95:5:1%) to give the title compound as a yellow oil (1.09 g, 87%); 1H NMR (300 MHz, CDCl3) δ 7.52(d, 1H, J=8.57 Hz), 6.97(d, 1H, J=2.15 Hz), 6.83(dd, 1H, J=8.54, 2.18 Hz), 4.81(s, 2H, CH2), 3.83(s, 3H, OMe), 0.93(s, 9H), 0.91(s, 9H), 0.34(s, 6H), 0.11(s, 6H).

Workup

  1. customwas deoxygenated 4 times by evacuation and backfilling with nitrogen
  2. customthe reaction vessel was degassed twice with nitrogen
  3. customthe solvent was removed by distillation under vacuum
  4. dissolutionThe residue was dissolved in ethyl acetate (75 mL)
  5. stirringstirred well
  6. filtrationfiltered
  7. additiontreated with triethylamine (5 mL)
  8. concentrationThe solution was concentrated onto silica gel (10 g)
  9. custompurified by flash chromatography (silica gel, eluent=hexane/diethyl ether/triethylamine; 95:5:1%)

Sources & evidence

ORD record
ord-6f8bba8a96574026bcb146c285ba8966
Source dataset
uspto-grants-2012_06
Patent number
US08198466B2

Reaction notes

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