Hydrochloric Acid → HCID 131723321, compound

HRID 2188224Notes

Reaction equation

HRID 2188224 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:8]([N:10]1[CH2:24][CH2:23][CH2:22][C@H:11]1[C:12]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:13])=[O:9])[CH2:3][C:4](=[O:7])[O:5][CH3:6].[ClH:32]>C(OCC)(=O)C>[NH2:1][C@H:2]([C:8]([N:10]1[CH2:24][CH2:23][CH2:22][C@H:11]1[C:12]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:13])=[O:9])[CH2:3][C:4](=[O:7])[O:5][CH3:6].[ClH:32]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10895356HCID 10895356, compound

Product 1

HCID 131723321HCID 131723321, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Conditions

Temperature
0 °C

Procedure

Boc-Asp(OMe)-Pro-OBzl (7.25 g) was dissolved in dry ethyl acetate (25 ml) and cooled in ice. Ethyl acetate saturated with hydrochloric acid (45 ml) was added and the mixture was stirred at 0° C. for 5 h. The excess of hydrochloric acid was removed by a nitrogen-flow and the resulting solution was concentrated in vacuo yielding H-Asp(OMe)-Pro-OBzl.HCl as a white solid (6.21 g).

Workup

  1. temperaturecooled in ice
  2. customThe excess of hydrochloric acid was removed by a nitrogen-flow
  3. concentrationthe resulting solution was concentrated in vacuo

Sources & evidence

ORD record
ord-051fef5f277342efae8355e4d186abdb
Source dataset
uspto-grants-2002_06
Patent number
US06410684B1

Reaction notes

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