4-(Trifluoromethyl)phenylhydrazine → 4-(Trifluoromethyl)aniline

HRID 2188254Notes

Reaction equation

HRID 2188254 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][C:6]([NH:9]N)=[CH:5][CH:4]=1>[Ni].CO>[F:1][C:2]([F:11])([F:12])[C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][CH:4]=1

Participants

4

Reactant 1

HCID 1362004-(Trifluoromethyl)phenylhydrazine

Product 1

HCID 99644-(Trifluoromethyl)anilineYield 100%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

Raney nickel (2 g) was added to a solution of 4-trifluoromethylphenylhydrazine (1 g) in methanol (5 ml) and heated at reflux for 1 hour. The cooled mixture was filtered and evaporated to give the title compound in 100% yield.

Workup

  1. temperatureheated
  2. temperatureat reflux for 1 hour
  3. filtrationThe cooled mixture was filtered
  4. customevaporated

Sources & evidence

ORD record
ord-6b0bc3e7a6ff4574a7acf176eabbca6b
Source dataset
uspto-grants-2002_06
Patent number
US06410737B1

Reaction notes

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