反应详情

温度

65 °C

Add 215 mg (4.3 mmol) of hydrazine hydrate at RT to 100 mg (0.215 mmol) of 3-{[5-(4-methoxy-phenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenylacetic acid methyl ester (Example 28), dissolved in 1.5 ml of THF and 2 ml of methanol. Stir the mixture at 65° C. for 1 h and at RT overnight and then concentrate under reduced pressure. After stirring with diisopropyl ether, filter off the solid with suction and dry under reduced pressure. 89.3 mg (89.3% of theory) of the target product are obtained.

1. concentrationat RT overnight and then concentrate under reduced pressure
2. stirringAfter stirring with diisopropyl ether
3. filtrationfilter off the solid with suction
4. customdry under reduced pressure
5. custom89.3 mg (89.3% of theory) of the target product are obtained