Sodium Hydroxide → HCID 67160427, compound

HRID 2189104Notes

Reaction equation

HRID 2189104 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:16]([NH:18][C:19]4[CH:20]=[C:21]([CH2:25][CH2:26][C:27]([OH:29])=[O:28])[CH:22]=[CH:23][CH:24]=4)=[N:15][CH:14]=[N:13][C:12]=3[O:11][C:10]=2[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[CH:5][CH:4]=1.[OH-].[Na+:37]>C1COCC1>[Na+:37].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[C:17]3[C:16]([NH:18][C:19]4[CH:20]=[C:21]([CH2:25][CH2:26][C:27]([O-:29])=[O:28])[CH:22]=[CH:23][CH:24]=4)=[N:15][CH:14]=[N:13][C:12]=3[O:11][C:10]=2[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 25095388HCID 25095388, compound

Product 1

HCID 67160427HCID 67160427, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Dissolve 150 mg (0.322 mmol) of 3-(3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)propanoic acid in 5 ml of THF and add 0.322 ml of 1N sodium hydroxide solution. Stir the mixture at RT for 1 h, then concentrate under reduced pressure and dry the residue under high vacuum overnight. 155.7 mg (99.1% of theory) of the target product are obtained as a colourless solid.

Workup

  1. concentrationconcentrate under reduced pressure
  2. customdry the residue under high vacuum overnight
  3. custom155.7 mg (99.1% of theory) of the target product are obtained as a colourless solid

Sources & evidence

ORD record
ord-0633e7bd2c2e4f278a632ac1a9f5a7f0
Source dataset
uspto-grants-2012_12
Patent number
US08324222B2

Reaction notes

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