Urea → HCID 178488028, compound

HRID 2189228Notes

Reaction equation

HRID 2189228 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=O.[NH2:13][C:14](N)=[O:15]>O>[CH3:12][O:11][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[N:1]=[C:14]([OH:15])[N:13]=[C:4]2[OH:6]

Participants

4

Reactant 2

HCID 1176UreaHCID 2779305-Methoxyanthranilic acid

Product 1

HCID 178488028HCID 178488028, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-Amino-5-methoxybenzoic acid (5.090 g, 30.45 mmol) was heated with urea (18.300 g, 304.50 mmol) to 150° C. for 24 h. Water (150 mL) was cautiously added to the melt and allowed to cool. The resulting precipitate was filtered off and dried to give a solid (4.189 g, 72%).

Workup

  1. temperatureto cool
  2. filtrationThe resulting precipitate was filtered off
  3. customdried

Sources & evidence

ORD record
ord-80b804466daa4cb7b57bb05f2b8950a5
Source dataset
uspto-grants-2012_12
Patent number
US08324226B2

Reaction notes

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