Trifluoroacetic acid → HCID 44251385, compound

HRID 2189472Notes

Reaction equation

HRID 2189472 reaction equation
C(OC([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([C:17](=[O:34])[N:18]([CH3:33])[C:19]2[CH:20]=[N:21][C:22]([O:25][C:26]3[C:27]([CH3:32])=[N:28][CH:29]=[CH:30][CH:31]=3)=[CH:23][CH:24]=2)=[CH:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[CH3:33][N:18]([C:19]1[CH:20]=[N:21][C:22]([O:25][C:26]2[C:27]([CH3:32])=[N:28][CH:29]=[CH:30][CH:31]=2)=[CH:23][CH:24]=1)[C:17]([C:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[NH:8][CH:9]=1)=[O:34]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68968247HCID 68968247, compound

Product 1

HCID 44251385HCID 44251385, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The tert-butyl-3-(methyl(6-(2-methylpyridine-3-yloxy)pyridine-3-yl)carbamoyl)-1H-indole-1-carboxylate (40 mg, 0.087 mmol) was added to a mixed solution of dichloromethane (1 ml) and TFA (1 ml), and the mixture was stirred at room temperature for 1 hour. Subsequently, the product was filtered, washed, and dried to yield a target compound as a white solid (28 mg, 90%)

Workup

  1. filtrationSubsequently, the product was filtered
  2. washwashed
  3. customdried

Sources & evidence

ORD record
ord-ea81bc2a180547b68c05949e97f83314
Source dataset
uspto-grants-2012_12
Patent number
US08324246B2

Reaction notes

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