Hydroxyamine hydrochloride → HCID 178471847, compound

HRID 2189779Notes

Reaction equation

HRID 2189779 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[N:7]=[CH:6]2)#[N:2].C(=O)(O)[O-].[Na+].Cl.[NH2:25][OH:26]>C(O)C>[OH:26][NH:25][C:1](=[NH:2])[C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[N:7]=[CH:6]2

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 59316705Ethyl 3-(5-cyano-1H-indazol-1-yl)propanoate

Product 1

HCID 178471847HCID 178471847, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

Ethyl 3-(5-cyano-1H-indazol-1-yl)propanoate (D47) (1 g, 4.11 mmol) was dissolved in ethanol (30 ml) and sodium bicarbonate (1.73 g, 20.55 mmol) and hydroxylamine hydrochloride (571 mg, 8.22 mmol) were added. The reaction was heated at 50° C. overnight and then allowed to cool. The reaction mixture was filtered and the residue washed with ethanol. The filtrate was evaporated to dryness in vacuo and the resultant crude title compound (1.06 g) was used the subsequent reactions.

Workup

  1. temperatureto cool
  2. filtrationThe reaction mixture was filtered
  3. washthe residue washed with ethanol
  4. customThe filtrate was evaporated to dryness in vacuo

Sources & evidence

ORD record
ord-88147cee73f647489fbcef919bffe2c4
Source dataset
uspto-grants-2012_12
Patent number
US08324254B2

Reaction notes

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