Hydroxyamine hydrochloride → HCID 178471848, compound

HRID 2189791Notes

Reaction equation

HRID 2189791 reaction equation
[C:1]([C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[N:6][N:7]2[CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])#[N:2].Cl.[NH2:20][OH:21].C(=O)(O)[O-].[Na+]>C(O)C>[OH:21][NH:20][C:1](=[NH:2])[C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[N:6][N:7]2[CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 59316734Ethyl 3-(4-cyano-1H-indazol-1-yl)propanoate

Product 1

HCID 178471848HCID 178471848, compoundYield 70.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 3-(4-cyano-1H-indazol-1-yl)propanoate (D96) (0.95 g, 3.91 mmol), hydroxylamine hydrochloride (1.086 g, 15.62 mmol), and sodium bicarbonate (3.28 g, 39.1 mmol), were heated in ethanol (20 ml) at 50° C. for 3 hours. The mixture was filtered and evaporated to give the title compound (760 mg) as a white powder. MS (ES): C13H16N4O3 requires 276; found (MH+) 277.

Workup

  1. filtrationThe mixture was filtered
  2. customevaporated

Sources & evidence

ORD record
ord-117b5d196a694df08a31c9cc25167a0f
Source dataset
uspto-grants-2012_12
Patent number
US08324254B2

Reaction notes

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