Hydrochloric Acid → HCID 68553917, compound

HRID 2189941Notes

Reaction equation

HRID 2189941 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[S:13][C:12]([CH2:20][CH2:21][C:22]#[N:23])([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:11]([C:24](=[O:29])[C@@H:25]([O:27][CH3:28])[CH3:26])[N:10]=1.[ClH:30].[CH2:31]([OH:33])[CH3:32]>>[ClH:30].[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[S:13][C:12]([CH2:20][CH2:21][C:22](=[NH:23])[O:33][CH2:31][CH3:32])([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:11]([C:24](=[O:29])[C@@H:25]([O:27][CH3:28])[CH3:26])[N:10]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 68549380HCID 68549380, compound

Product 1

HCID 68553917HCID 68553917, compound

Conditions

Temperature
0 °C

Procedure

To a cooled (0° C.) solution of 3-(5-(2,5-difluorophenyl)-3-((S)-2-methoxypropanoyl)-2-phenyl-2,3-dihydro-1,3,4-thiadiazol-2-yl)propanenitrile (0.041 g, 0.090 mmol, Example 14, Step C) in ethanol (0.5 mL) was added 9.8 M ethanolic HCl (0.5 mL, 4.9 mmol). After stirring at 0° C. for 1 hour and then at ambient temp for 8 hours, the mixture was concentrated under reduced pressure to provide the product.

Workup

  1. waitat ambient temp for 8 hours
  2. concentrationthe mixture was concentrated under reduced pressure
  3. customto provide the product

Sources & evidence

ORD record
ord-0415e96b80ee49dc9fdbe9a0a29d8b0e
Source dataset
uspto-grants-2012_12
Patent number
US08324257B2

Reaction notes

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