反应详情

温度

0 °C

To a cooled (0° C.) solution of tert-butyl hydroxycarbamate (1.90 g, 14.2 mmol) in THF (30 mL) was added NaH (0.285 g, 11.9 mmol). After stirring at 0° C. for 5 minutes and at room temperature for 10 minutes, the mixture was added to a solution of 3-chloro-1-phenylpropan-1-one (2.00 g, 11.9 mmol) in THF (10 mL). After stirring at room temperature for 30 minutes, the mixture was filtered, and the filtrate was concentrated under reduced pressure. The residue was chromatographed (20% ethyl acetate in hexanes) to provide the product (2.20 g, 69%) as a white solid.

1. stirringAfter stirring at room temperature for 30 minutes
2. filtrationthe mixture was filtered
3. concentrationthe filtrate was concentrated under reduced pressure
4. customThe residue was chromatographed (20% ethyl acetate in hexanes)