Hydrochloric Acid → HCID 131730087, compound

HRID 2189982Notes

Reaction equation

HRID 2189982 reaction equation
[CH:1]1([CH2:4][C:5]2([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]2)[CH2:3][CH2:2]1.[ClH:23]>O1CCOCC1>[ClH:23].[CH2:21]([O:20][C:18]([C:5]1([CH2:4][CH:1]2[CH2:2][CH2:3]2)[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1)=[O:19])[CH3:22]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21061057HCID 21061057, compound

Product 1

HCID 131730087HCID 131730087, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A mixture of 0.5 g (1.6 mmol) 1-tert-butyl 4-ethyl 4-(cyclopropylmethyl)piperidine-1,4-dicarboxylate (commercially available) in 20 mL dioxane was treated with 4 mL 4N HCl in dioxane and stirred at room temperature over night. The mixture was evaporated to dryness and used without further purification in the consecutive step.

Workup

  1. customThe mixture was evaporated to dryness
  2. customused without further purification in the consecutive step

Sources & evidence

ORD record
ord-ee80fb416204499da46591ef2c6d41d2
Source dataset
uspto-grants-2012_12
Patent number
US08324250B2

Reaction notes

Loading…