反应详情

DEAD (1.2 eq., 2.64 g) was added to a solution of methyl 2,2-bis(hydroxymethyl)pent-4-enoate (1 eq., 2.2 g), Ziram® (1.2 eq., 4.64 g) and triphenylphosphine (1.2 eq., 3.98 g) in PhMe (32 ml). The mixture was stirred at room temperature for 2 days and filtered. The filter cake was washed with 3×DCM. The filtrate was concentrated at 50 torr and 40° C. Silica gel chromatography using straight DCM yields the title compound as colorless oil (1.27 g, 64%).

1. filtrationfiltered
2. washThe filter cake was washed with 3×DCM
3. concentrationThe filtrate was concentrated at 50 torr and 40° C