HCID 57387821, compound → HCID 57388052, compound

HRID 2190512Notes

Reaction equation

HRID 2190512 reaction equation
[CH:1]1([C:4]([NH:6][C:7]2[N:11]([CH3:12])[C:10]3[CH:13]=[C:14]([O:17][C:18]4[CH:19]=[C:20]([NH:24]C(=O)OC(C)(C)C)[CH:21]=[CH:22][CH:23]=4)[CH:15]=[CH:16][C:9]=3[N:8]=2)=[O:5])[CH2:3][CH2:2]1>FC(F)(F)C(O)=O>[NH2:24][C:20]1[CH:19]=[C:18]([CH:23]=[CH:22][CH:21]=1)[O:17][C:14]1[CH:15]=[CH:16][C:9]2[N:8]=[C:7]([NH:6][C:4]([CH:1]3[CH2:3][CH2:2]3)=[O:5])[N:11]([CH3:12])[C:10]=2[CH:13]=1

Participants

3

Reactant 1

HCID 57387821HCID 57387821, compound

Product 1

HCID 57388052HCID 57388052, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Using tert-butyl [3-({2-[(cyclopropylcarbonyl)amino]-1-methyl-1H-benzimidazol-6-yl}oxy)phenyl]carbamate (1.52 g, 3.60 mmol) and trifluoroacetic acid (50 mL) as starting materials, and in the same manner as in Example C1(vi), the title compound (1.02 g, 88%) was obtained as a pink amorphous substance.

Sources & evidence

ORD record
ord-35fd208fc7d04512a17cb1e070e13839
Source dataset
uspto-grants-2012_12
Patent number
US08324395B2

Reaction notes

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