Chloride → HCID 59317999, compound

HRID 2190534Notes

Reaction equation

HRID 2190534 reaction equation
[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][C:8](N)=[CH:9][CH:10]=2)[CH:5]=[CH:4]1)[CH3:2].[Cl-].[Cl:14][C:15]1[CH:31]=[CH:30][C:18]([C:19]([NH:21]C2C=CC(I)=C(C)C=2)=[O:20])=[CH:17][N:16]=1>>[Cl:14][C:15]1[CH:31]=[CH:30][C:18]([C:19]([NH:21][C:9]2[CH:10]=[C:11]3[C:6]([CH:5]=[CH:4][N:3]3[CH2:1][CH3:2])=[CH:7][CH:8]=2)=[O:20])=[CH:17][N:16]=1

Participants

4

Reactant 3

HCID 312ChlorideHCID 184755341-ethyl-1H-indol-5-amineHCID 593181386-chloro-N-(4-iodo-3-methyl-phenyl)-nicotinamide

Product 1

HCID 59317999HCID 59317999, compound

Procedure

6-Chloro-N-(1-ethyl-1H-indol-6-yl)-nicotinamide was prepared from 1-ethyl-1H-indol-5-ylamine (prepared as described in J. Med. Chem. 2007, 5509), and 6-chloronicotincyl chloride in a procedure similar to the one described in the synthesis of 6-chloro-N-(4-Iodo-3-methyl-phenyl)-nicotinamide, above. LCMS calcd for C16H14ClN3O (m/e) 299, obsd 300 (M+H).

Sources & evidence

ORD record
ord-973ba1016a7e425e9a72b68eeadf3e2a
Source dataset
uspto-grants-2012_12
Patent number
US08324385B2

Reaction notes

Loading…