反应详情

A mixture of 0.8 g of N-(2-hydroxy-4-trifluoromethylphenyl)isonicotinamide, 15 ml of carbon tetrachloride, 2.23 g of triphenylphosphine and 0.86 g of triethylamine was heated to reflux for five hours. The mixture was cooled to room temperature. Then, water was poured into the mixture, followed by extraction with ethyl acetate twice. The combined organic layers were washed with water and a saturated sodium chloride solution, dried over magnesium sulfate, and then concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to give 0.25 g of 2-(pyridin-4-yl)-6-(trifluoromethyl)benzoxazole (hereinafter, referred to as “active compound 15”).

1. temperaturewas heated
2. temperatureto reflux for five hours
3. extractionfollowed by extraction with ethyl acetate twice
4. washThe combined organic layers were washed with water
5. dry with materiala saturated sodium chloride solution, dried over magnesium sulfate
6. concentrationconcentrated under reduced pressure