Sodium Hydroxide → HCID 54746571, compound

HRID 2190923Notes

Reaction equation

HRID 2190923 reaction equation
C([O:3][C:4](=[O:22])[CH2:5][NH:6][C:7]([C:9]1[C:10](=[O:21])[O:11][C:12]2[C:17]([C:18]=1[OH:19])=[CH:16][CH:15]=[C:14]([CH3:20])[CH:13]=2)=[O:8])C.[OH-].[Na+]>O1CCCC1.CO.O>[OH:19][C:18]1[C:17]2[C:12](=[CH:13][C:14]([CH3:20])=[CH:15][CH:16]=2)[O:11][C:10](=[O:21])[C:9]=1[C:7]([NH:6][CH2:5][C:4]([OH:22])=[O:3])=[O:8]

Participants

6

Reactant 2

HCID 14798Sodium HydroxideHCID 86649469HCID 86649469, compound

Product 1

HCID 54746571HCID 54746571, compoundYield 83.2%

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of [(4-hydroxy-7-methyl-2-oxo-2H-chromene-3-carbonyl)-amino]-acetic acid ethyl ester (106 mg, 0.347 mmol) and NaOH solution (0.70 mL, 1.38 mmol) in tetrahydrofuran (3 mL), methanol (3 mL) and water (3 mL) was stirred at rt overnight; the solvents were evaporated and the resulting residue was dissolved in water, acidified with 2 M HCl solution, the precipitates were then dried to give the desired product (80 mg). ESI (m/z): 278 (M+H)+.

Workup

  1. customthe solvents were evaporated
  2. dissolutionthe resulting residue was dissolved in water
  3. customthe precipitates were then dried

Sources & evidence

ORD record
ord-42208de58e46402aaa2232e8105661e2
Source dataset
uspto-grants-2012_12
Patent number
US08324405B2

Reaction notes

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