HCID 136381454, compound → HCID 136381455, compound

HRID 2191029Notes

Reaction equation

HRID 2191029 reaction equation
[OH:1][CH:2]1[CH:6]([OH:7])[CH:5]([N:8]2[CH:16]=[N:15][C:14]3[C:13](=[O:17])[NH:12][C:11]([NH:18]C(=O)C(C)C)=[N:10][C:9]2=3)[O:4][CH:3]1[CH:24]=[CH:25][P:26](=[O:29])([OH:28])[OH:27]>[NH4+].[OH-]>[NH2:18][C:11]1[NH:12][C:13](=[O:17])[C:14]2[N:15]=[CH:16][N:8]([CH:5]3[O:4][CH:3]([CH:24]=[CH:25][P:26](=[O:27])([OH:29])[OH:28])[CH:2]([OH:1])[CH:6]3[OH:7])[C:9]=2[N:10]=1

Participants

3

Reactant 1

HCID 136381454HCID 136381454, compound

Product 1

HCID 136381455HCID 136381455, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 14923Ammonium HydroxideSolvent

Procedure

Compound 18.8 (180 mg, 54% yield) was synthesized from compound 18.5 (400 mg, 0.932 mmol) by treating 18.5 with concentrated NH4OH (10 ml) at 45° C. for 30 min. 1H NMR (D2O, 300 MHz) 7.98 (s, 1H), 6.41 (m, 1H), 5.95 (m, 1H), 5.75 (d, J=5.4 Hz, 1H), 4.63 (m, 1H), 4.49 (m, 1H), 4.19 (t, J=4.5 Hz, 1H), 31P NMR (D2O, 121.4 MHz) 9.7; MS (ESI) m/z 360 [M+H]+

Sources & evidence

ORD record
ord-68c4410ddbfe4dfca54dfeee6d1282fd
Source dataset
uspto-grants-2012_12
Patent number
US08324179B2

Reaction notes

Loading…