Hydrogen Peroxide → HCID 136351465, compound

HRID 2191050Notes

Reaction equation

HRID 2191050 reaction equation
[NH2:1][C:2]1[NH:3][C:4](=[O:31])[C:5]2[N:6]=[CH:7][N:8]([C@@H:11]3[O:15][C@H:14]([CH2:16][CH:17]([P:25](=[O:28])([OH:27])[OH:26])[S:18][C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[C@@H:13]([F:29])[C@H:12]3[OH:30])[C:9]=2[N:10]=1.OO.S([O-])([O-])=[O:35].[Na+].[Na+]>O>[NH2:1][C:2]1[NH:3][C:4](=[O:31])[C:5]2[N:6]=[CH:7][N:8]([C@@H:11]3[O:15][C@H:14]([CH2:16][CH:17]([P:25](=[O:27])([OH:26])[OH:28])[S:18]([C:19]4[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=4)=[O:35])[C@@H:13]([F:29])[C@H:12]3[OH:30])[C:9]=2[N:10]=1

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 24437Sodium SulfiteHCID 136173376HCID 136173376, compound

Product 1

HCID 136351465HCID 136351465, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
90 °C

Procedure

Compound 35.17 (15 mg, 0.032 mmol) was suspended in 3 mL water, and treated with 30% hydrogen peroxide (100 mL). The mixture was heated to 90° C. for 3 h and sodium sulfite (113 mg, 0.9 mmol) was added to quench the peroxide. The solvent was removed under reduced pressure and the residue was subjected to a reverse phase HPLC to give compound 35.18 (12 mg, 77% yield).

Workup

  1. customto quench the peroxide
  2. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-67811de63c014379931a608fd2577b90
Source dataset
uspto-grants-2012_12
Patent number
US08324179B2

Reaction notes

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