Hydrochloric Acid → HCID 131730098, compound

HRID 2191125Notes

Reaction equation

HRID 2191125 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][CH2:9][CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH:11]2[C:16]2[CH:21]=[CH:20][C:19](F)=[C:18](F)[CH:17]=2)=[N:6][CH:7]=1.Cl.[C:25]([O:29]C(N1CCCC(C2C=CC(OC)=CC=2)C1)=O)(C)(C)C>>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][CH2:9][CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH:11]2[C:16]2[CH:21]=[CH:20][C:19]([O:29][CH3:25])=[CH:18][CH:17]=2)=[N:6][CH:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 68479046HCID 68479046, compoundHCID 102106855HCID 102106855, compound

Product 1

HCID 131730098HCID 131730098, compound

Procedure

In analogy to the procedure described for the synthesis of 5-Chloro-2-[(3SR,4SR)-3-(3,4-difluoro-phenyl)-piperidin-4-ylmethoxy]-pyridine; hydrochloride the title compound was prepared from 445-Chloro-pyridin-2-yloxymethyl)-3-(4-methoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester as off-white foam (1:1 mixture cis:trans). MS (m/e): 333.4 [(M+H)+].

Sources & evidence

ORD record
ord-c8950c947a68429aa9917ba0509c9c97
Source dataset
uspto-grants-2012_12
Patent number
US08324248B2

Reaction notes

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