Hydrochloric Acid → HCID 131730099, compound

HRID 2191126Notes

Reaction equation

HRID 2191126 reaction equation
[Cl:1]C1C=CC(OCC2CCNCC2C2C=CC(F)=C(F)C=2)=NC=1.Cl.C(OC([N:32]1[CH2:37][CH2:36][CH:35]([CH2:38][O:39][C:40]2[CH:45]=[CH:44][C:43]([Cl:46])=[CH:42][N:41]=2)[CH:34]([C:47]2[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=2)[CH2:33]1)=O)(C)(C)C>>[ClH:1].[Cl:46][C:43]1[CH:44]=[CH:45][C:40]([O:39][CH2:38][C@H:35]2[CH2:36][CH2:37][NH:32][CH2:33][C@@H:34]2[C:47]2[CH:48]=[CH:49][CH:50]=[CH:51][CH:52]=2)=[N:41][CH:42]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 68475948HCID 68475948, compoundHCID 68479046HCID 68479046, compound

Product 1

HCID 131730099HCID 131730099, compound

Procedure

In analogy to the procedure described for the synthesis of 5-Chloro-2-[(3SR,4SR)-3-(3,4-difluoro-phenyl)-piperidin-4-ylmethoxy]-pyridine; hydrochloride the title compound was prepared from (3SR,4 SR)-4-(5-Chloro-pyridin-2-yloxymethyl)-3-phenyl-piperidine-1-carboxylic acid tert-butyl ester as off-white foam. MS (m/e): 303.3 [(M+H)+].

Sources & evidence

ORD record
ord-5a753f47b9e54c47a9addf6f1dd50d79
Source dataset
uspto-grants-2012_12
Patent number
US08324248B2

Reaction notes

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