反应详情

温度

50 °C

To a solution of 4,4-dimethylpiperidine-2,6-dione (2.0 g, 14.2 mmol) in acetone (50 mL) was added K2CO3 (3.92 g, 28.3 mmol) followed by (bromomethyl)benzene (1.85 mL, 15.6 mmol). The reaction mixture was heated at 50° C. for 4 h then cooled to room temperature and stirred overnight. The thick white precipitate present was removed via filtration, rinsing with acetone. The filtrate was concentrated and purified by SiO2 chromatography (10% to 50% EtOAc/hexanes) to afford 3.0 g (92%) of 1-benzyl-4,4-dimethylpiperidine-2,6-dione as a white solid.

1. temperaturethen cooled to room temperature
2. customThe thick white precipitate present was removed via filtration
3. washrinsing with acetone
4. concentrationThe filtrate was concentrated
5. custompurified by SiO2 chromatography (10% to 50% EtOAc/hexanes)