Hydrochloric Acid → 1350473-55-0

HRID 2191592Notes

Reaction equation

HRID 2191592 reaction equation
C(OC(=O)[NH:7][C:8]1([C:13]([CH:15]2[CH2:17][CH2:16]2)=[O:14])[CH2:12][CH2:11][CH2:10][CH2:9]1)(C)(C)C.CO.[ClH:21]>>[ClH:21].[NH2:7][C:8]1([C:13]([CH:15]2[CH2:17][CH2:16]2)=[O:14])[CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 67002375HCID 67002375, compound

Product 1

HCID 670020501350473-55-0Yield 98%

Procedure

In a 10 mL round-bottomed flask (1-cyclopropanecarbonyl-cyclopentyl)-carbamic acid tert-butyl ester (61 mg, 0.24 mmol) was dissolved in 1.0 M HCl solution in MeOH (1.5 mL, 1.5 mmol). The reaction mixture was stirred at room temperature overnight then concentrated under reduced pressure to afford 45 mg (98%) of (1-amino-cyclopentyl)-cyclopropyl-methanone hydrochloride as a white solid.

Workup

  1. concentrationthen concentrated under reduced pressure

Sources & evidence

ORD record
ord-9812656e644648a8b9d6765215e936ea
Source dataset
uspto-grants-2012_12
Patent number
US08329699B2

Reaction notes

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