Hydrazine hydrate (1:1) → 2-Chloro-3-hydrazinylpyrazine hydrochloride

HRID 2191608Notes

Reaction equation

HRID 2191608 reaction equation
[Cl:1][C:2]1[C:7](Cl)=[N:6][CH:5]=[CH:4][N:3]=1.O.[NH2:10][NH2:11]>C(O)C>[ClH:1].[Cl:1][C:2]1[C:7]([NH:10][NH2:11])=[N:6][CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 785752,3-Dichloropyrazine

Product 1

HCID 534027422-Chloro-3-hydrazinylpyrazine hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2,3-dichloropyrazine (3.822 g, 25.65 mmol) in absolute ethanol (20 mL) was treated with hydrazine hydrate (2.74 mL) at room temperature. The mixture was stirred for 3 days then filtered and washed with ethanol (20 mL) to yield 2-chloro-3-hydrazinylpyrazine hydrochloride as an off-white fluffy solid (4.04 g).

Workup

  1. filtrationthen filtered
  2. washwashed with ethanol (20 mL)

Sources & evidence

ORD record
ord-5eb99081f7bc4739b100dc9d257babdf
Source dataset
uspto-grants-2012_12
Patent number
US08329705B2

Reaction notes

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