HCID 68956418, compound → HCID 68959277, compound

HRID 2191650Notes

Reaction equation

HRID 2191650 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([C:9]2[CH:21]=[CH:20][C:12]([C:13]([O:15]C(C)(C)C)=[O:14])=[C:11]([NH:22][C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=3)[CH:10]=2)[CH:6]=[CH:7][CH:8]=1)#[N:2]>FC(F)(F)C(O)=O>[C:1]([C:3]1[CH:4]=[C:5]([C:9]2[CH:21]=[CH:20][C:12]([C:13]([OH:15])=[O:14])=[C:11]([NH:22][C:23]3[CH:24]=[CH:25][C:26]([F:29])=[CH:27][CH:28]=3)[CH:10]=2)[CH:6]=[CH:7][CH:8]=1)#[N:2]

Participants

3

Reactant 1

HCID 68956418HCID 68956418, compound

Product 1

HCID 68959277HCID 68959277, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Trifluoroacetic acid 10 mL was added to the obtained tert-butyl 4-(3-cyanophenyl)-2-(4-fluoroanilino)benzoate, and it was stirred at room temperature for 1 hour. The solvent was removed under reduced pressure, methanol was added to the obtained residue, and solid matter was filtrated to give 4-(3-cyanophenyl)-2-(4-fluoroanilino)benzoic acid 13 mg of pale yellow solid.

Workup

  1. customThe solvent was removed under reduced pressure, methanol
  2. additionwas added to the obtained residue, and solid matter
  3. filtrationwas filtrated

Sources & evidence

ORD record
ord-fe2bb9064cf4492b9d74e47692d0721c
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

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