HCID 68960562, compound → HCID 57668005, compound

HRID 2191663Notes

Reaction equation

HRID 2191663 reaction equation
[CH:1]1([C:6]2[CH:18]=[CH:17][C:9]([C:10]([O:12]C(C)(C)C)=[O:11])=[C:8]([NH:19][C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)[CH:7]=2)[CH2:5][CH2:4][CH:3]=[CH:2]1>FC(F)(F)C(O)=O>[CH:1]1([C:6]2[CH:18]=[CH:17][C:9]([C:10]([OH:12])=[O:11])=[C:8]([NH:19][C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)[CH:7]=2)[CH2:5][CH2:4][CH:3]=[CH:2]1

Participants

3

Reactant 1

HCID 68960562HCID 68960562, compound

Product 1

HCID 57668005HCID 57668005, compoundYield 96.9%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Trifluoroacetic acid 10 mL was added to tert-butyl 4-(2-cyclopenten-1-yl)-2-(4-fluoroanilino)benzoate 27 mg, and it was stirred at room temperature for 1 hour. The solvent was removed under reduced pressure, methanol was added to the obtained residue, and solid matter was filtrated to give 4-(2-cyclopenten-1-yl)-2-(4-fluoroanilino)benzoic acid 22 mg of white solid.

Workup

  1. customThe solvent was removed under reduced pressure, methanol
  2. additionwas added to the obtained residue, and solid matter
  3. filtrationwas filtrated

Sources & evidence

ORD record
ord-2329f8b79f1b49b38d6720f3fab58c29
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

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