Trifluoroacetic acid → HCID 57667999, compound

HRID 2191678Notes

Reaction equation

HRID 2191678 reaction equation
FC(F)(F)C(O)=O.[CH2:8]([NH:15][C:16]1[CH:28]=[C:27]([CH2:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH:26]=[CH:25][C:17]=1[C:18]([O:20]C(C)(C)C)=[O:19])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[CH2:8]([NH:15][C:16]1[CH:28]=[C:27]([CH2:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH:26]=[CH:25][C:17]=1[C:18]([OH:20])=[O:19])[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68961718Tert-butyl 2-(benzylamino)-4-phenethylbenzoate

Product 1

HCID 57667999HCID 57667999, compoundYield 80.4%

Procedure

Trifluoroacetic acid 2.0 mL was added to tert-butyl 2-(benzylamino)-4-phenethylbenzoate 0.16 g, it was stirred at room temperature 4 hours, and the solvent was removed under reduced pressure. Toluene was added to it, and the solvent was removed under reduced pressure. Diisopropyl ether and hexane were added to the obtained residue, solid matter was filtrated to give 2-(benzylamino)-4-phenethylbenzoic acid 0.11 g of white solid.

Workup

  1. customthe solvent was removed under reduced pressure
  2. additionToluene was added to it
  3. customthe solvent was removed under reduced pressure
  4. additionDiisopropyl ether and hexane were added to the obtained residue, solid matter
  5. filtrationwas filtrated

Sources & evidence

ORD record
ord-edfd729b472742c287c9044e934bd238
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

Loading…