Methanol → HCID 57667845, compound

HRID 2191692Notes

Reaction equation

HRID 2191692 reaction equation
[OH-].[Na+].CO.[F:5][C:6]1[CH:30]=[CH:29][C:9]([NH:10][C:11]2[CH:20]=[C:19]([CH2:21][O:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:18]=[CH:17][C:12]=2[C:13]([O:15]C)=[O:14])=[CH:8][CH:7]=1>O1CCCC1>[F:5][C:6]1[CH:30]=[CH:29][C:9]([NH:10][C:11]2[CH:20]=[C:19]([CH2:21][O:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:18]=[CH:17][C:12]=2[C:13]([OH:15])=[O:14])=[CH:8][CH:7]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 57667991HCID 57667991, compound

Product 1

HCID 57667845HCID 57667845, compoundYield 66.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2.0 mol/L Sodium hydroxide aqueous solution 0.92 mL was added to a mixed solution of methanol 2.0 mL and tetrahydrofuran 2.0 mL of methyl 2-(4-fluoroanilino)-4-(phenoxymethyl)benzoate 0.22 g, and it was stirred at room temperature for 24 hours. The solvent was removed under reduced pressure, water was added to it, and it was adjusted to pH4.0 with 1.0 mol/L hydrochloric acid. Solid matter was filtrated to give 2-(4-fluoroanilino)-4-(phenoxymethyl)benzoic acid 0.14 g of white solid.

Workup

  1. customThe solvent was removed under reduced pressure, water
  2. additionwas added to it, and it
  3. filtrationSolid matter was filtrated

Sources & evidence

ORD record
ord-8e344ecf25094654969f8094d86642f2
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

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