HCID 68958210, compound → HCID 68963099, compound

HRID 2191701Notes

Reaction equation

HRID 2191701 reaction equation
[F:1][C:2]1[CH:29]=[C:28]([F:30])[CH:27]=[CH:26][C:3]=1[NH:4][C:5]1[CH:17]=[C:16]([CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:15]=[CH:14][C:6]=1[C:7]([O:9]C(C)(C)C)=[O:8]>FC(F)(F)C(O)=O>[F:1][C:2]1[CH:29]=[C:28]([F:30])[CH:27]=[CH:26][C:3]=1[NH:4][C:5]1[CH:17]=[C:16]([CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:15]=[CH:14][C:6]=1[C:7]([OH:9])=[O:8]

Participants

3

Reactant 1

HCID 68958210HCID 68958210, compound

Product 1

HCID 68963099HCID 68963099, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Trifluoroacetic acid 10 mL was added to the obtained tert-butyl 2-(2,4-difluoroanilino)-4-phenethylbenzoate, and it was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure, methanol was added to the obtained residue, and solid matter was filtrated to give 2-(2,4-difluoroanilino)-4-phenethylbenzoic acid 59 mg of white solid.

Workup

  1. customThe solvent was removed under reduced pressure, methanol
  2. additionwas added to the obtained residue, and solid matter
  3. filtrationwas filtrated

Sources & evidence

ORD record
ord-9ab25a44f7c44f87bd25d9a2c307cfd3
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

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