Methanol → HCID 57668014, compound

HRID 2191735Notes

Reaction equation

HRID 2191735 reaction equation
CO.[F:3][C:4]1[CH:31]=[CH:30][C:7]([NH:8][C:9]2[CH:17]=[C:16](/[CH:18]=[CH:19]/[C:20]3[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=3)[CH:15]=[CH:14][C:10]=2[C:11]([OH:13])=[O:12])=[CH:6][CH:5]=1>[C].[Pd].C(OCC)(=O)C>[F:3][C:4]1[CH:5]=[CH:6][C:7]([NH:8][C:9]2[CH:17]=[C:16]([CH2:18][CH2:19][C:20]3[CH:25]=[CH:24][C:23]([C:26]([F:27])([F:28])[F:29])=[CH:22][CH:21]=3)[CH:15]=[CH:14][C:10]=2[C:11]([OH:13])=[O:12])=[CH:30][CH:31]=1

Participants

5

Reactant 2

HCID 887MethanolHCID 57668030HCID 57668030, compound

Product 1

HCID 57668014HCID 57668014, compoundYield 92.9%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a mixed solution of methanol 4.0 mL and ethyl acetate 4.0 mL of 2-(4-fluoroanilino)-4-((E)-2-(4-(trifluoromethyl)phenyl)vinyl)benzoic acid 15 mg was added 5% palladium-carbon 8.0 mg at room temperature, and it was stirred under hydrogen atmosphere at room temperature for 10 hours. The solvent was removed under reduced pressure after insoluble matter was filtrated to give 2-(4-fluoroanilino)-4-(2-(4-(trifluoromethyl)phenyl)ethyl)benzoic acid 14 mg of white solid.

Workup

  1. customThe solvent was removed under reduced pressure after insoluble matter
  2. filtrationwas filtrated

Sources & evidence

ORD record
ord-4a8d070e9ebd429ca5b597666d0f5f8a
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

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