HCID 68961390, compound → HCID 57667820, compound

HRID 2191756Notes

Reaction equation

HRID 2191756 reaction equation
[F:1][C:2]1[CH:28]=[CH:27][C:5]([NH:6][C:7]2[CH:19]=[C:18]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[CH:21]=3)[CH:17]=[CH:16][C:8]=2[C:9]([O:11]C(C)(C)C)=[O:10])=[CH:4][CH:3]=1>FC(F)(F)C(O)=O>[F:1][C:2]1[CH:28]=[CH:27][C:5]([NH:6][C:7]2[CH:19]=[C:18]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[CH:21]=3)[CH:17]=[CH:16][C:8]=2[C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 68961390HCID 68961390, compound

Product 1

HCID 57667820HCID 57667820, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Trifluoroacetic acid 10 mL was added to the obtained tert-butyl 2-(4-fluoroanilino)-4-(3-fluorophenyl)benzoate, and it was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure, hexane was added to the obtained residue, and solid matter was filtrated to give 2-(4-fluoroanilino)-4-(3-fluorophenyl)benzoic acid 56 mg of a yellow solid.

Workup

  1. customThe solvent was removed under reduced pressure, hexane
  2. additionwas added to the obtained residue, and solid matter
  3. filtrationwas filtrated

Sources & evidence

ORD record
ord-84918954e9ad422d862cf3ef0e3eb2d0
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

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