Ethyl Acetate → HCID 57667895, compound

HRID 2191795Notes

Reaction equation

HRID 2191795 reaction equation
[F:1][C:2]1[CH:30]=[CH:29][C:5]([NH:6][C:7]2[CH:15]=[C:14](/[CH:16]=[CH:17]/[C:18]3[CH:23]=[CH:22][C:21]([O:24][C:25]([F:28])([F:27])[F:26])=[CH:20][CH:19]=3)[CH:13]=[CH:12][C:8]=2[C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.C(OCC)(=O)C>[C].[Pd].CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:6][C:7]2[CH:15]=[C:14]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][C:25]([F:26])([F:27])[F:28])=[CH:20][CH:19]=3)[CH:13]=[CH:12][C:8]=2[C:9]([OH:11])=[O:10])=[CH:29][CH:30]=1

Participants

5

Reactant 2

HCID 8857Ethyl AcetateHCID 57667848HCID 57667848, compound

Product 1

HCID 57667895HCID 57667895, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

To the obtained 2-(4-fluoroanilino)-4-((E)-2-(4-(trifluoromethoxy)phenyl)vinyl)benzoic acid were added ethyl acetate 1.0 mL, methanol 1.0 mL and 10% palladium-carbon 2.0 mg sequentially, and it was stirred under hydrogen atmosphere at room temperature for 2 hours and 30 minutes. The solvent was removed under reduced pressure after insoluble matter was filtrated to give 2-(4-fluoroanilino)-4-(2-(4-(trifluoromethoxy)phenyl)ethyl)benzoic acid 3.4 mg of a white solid.

Workup

  1. customThe solvent was removed under reduced pressure after insoluble matter
  2. filtrationwas filtrated

Sources & evidence

ORD record
ord-8e30037d979a4a419739834373dd38cf
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

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