Trifluoroacetic acid → HCID 57668033, compound

HRID 2191810Notes

Reaction equation

HRID 2191810 reaction equation
FC(F)(F)C(O)=O.[CH3:8][S:9]([NH:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:31]=[CH:30][C:22]([C:23]([O:25]C(C)(C)C)=[O:24])=[C:21]([NH:32][C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=3[CH3:39])[CH:20]=2)=[CH:15][CH:14]=1)(=[O:11])=[O:10]>>[CH3:8][S:9]([NH:12][C:13]1[CH:14]=[CH:15][C:16]([C:19]2[CH:31]=[CH:30][C:22]([C:23]([OH:25])=[O:24])=[C:21]([NH:32][C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=3[CH3:39])[CH:20]=2)=[CH:17][CH:18]=1)(=[O:11])=[O:10]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68958028HCID 68958028, compound

Product 1

HCID 57668033HCID 57668033, compound

Procedure

Trifluoroacetic acid 5.0 mL was added to the obtained tert-butyl 4-(4-(methanesulfonamido)phenyl)-2-(2-methylanilino)benzoate, and it was stirred at room temperature for 3 hours. The solvent was removed under reduced pressure,diisopropyl ether was added to the obtained residue, solid matter was filtrated to give 4-(4-(methanesulfonamido)phenyl)-2-(2-methylanilino)benzoic acid 52 mg of a yellow solid.

Workup

  1. customThe solvent was removed under reduced pressure,diisopropyl ether
  2. additionwas added to the obtained residue, solid matter
  3. filtrationwas filtrated

Sources & evidence

ORD record
ord-cb285130230e4a5c8e0dd008547bf701
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

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