反应详情

温度

70 °C

To 2-methyl-2-propanol 3.0 mL solution of tert-butyl 2-amino-4-(indolin-1-yl)benzoate 0.12 g were added 3-iodophenol 0.22 g, cesium carbonate 0.26 g, tris(dibenzylideneacetone)dipalladium(0) 3.7 mg, palladium acetate 1.8 mg and 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl 9.5 mg at room temperature, and it was stirred at 70° C. for 12 hours. Tris(dibenzylideneacetone)dipalladium(0) 3.7 mg, palladium acetate 1.8 mg and 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl 9.5 mg were added to it, and it was stirred at 70° C. for 7 hours. Cesium carbonate 0.26 g, tris(dibenzylideneacetone)dipalladium(0) 3.7 mg, palladium acetate 1.8 mg and 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl 9.5 mg were added to it, and it was stirred at 70° C. for 12 hours. After the reaction mixture was cooled to room temperature, insoluble matter was filtrated, and ethyl acetate and 10% citric acid aqueous solution were added to it. The organic layer was separated and collected,dried over anhydrous magnesium sulfate after washing with saturated sodium chloride aqueous solution, and the solvent was removed under reduced pressure. The obtained residue was refined by silica gel column chromatography [Trikonex company, Flash Tube 2,008, eluent; hexane:ethyl acetate=4:1] to give tert-butyl 2-((3-hydroxyphenyl)amino)-4-(indolin-1-yl)benzoate.

1. stirringwas stirred at 70° C. for 7 hours
2. stirringwas stirred at 70° C. for 12 hours
3. temperatureAfter the reaction mixture was cooled to room temperature
4. filtrationinsoluble matter was filtrated
5. additionethyl acetate and 10% citric acid aqueous solution were added to it
6. customThe organic layer was separated
7. washafter washing with saturated sodium chloride aqueous solution
8. customthe solvent was removed under reduced pressure