Trifluoroacetic acid → HCID 57668061, compound

HRID 2191846Notes

Reaction equation

HRID 2191846 reaction equation
FC(F)(F)C(O)=O.[C:8]1([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[CH:13]=[CH:12][C:11]([NH:14][C:15]2[CH:27]=[C:26]([CH2:28][CH2:29][C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH:25]=[CH:24][C:16]=2[C:17]([O:19]C(C)(C)C)=[O:18])=[CH:10][CH:9]=1>ClCCl>[C:8]1([C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH:13]=[CH:12][C:11]([NH:14][C:15]2[CH:27]=[C:26]([CH2:28][CH2:29][C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH:25]=[CH:24][C:16]=2[C:17]([OH:19])=[O:18])=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68962151HCID 68962151, compound

Product 1

HCID 57668061HCID 57668061, compoundYield 61.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid 2.0 mL was added to dichloromethane 2.0 mL solution of tert-butyl 2-((biphenyl-4-yl)amino)-4-phenethylbenzoate 50 mg, and it was stirred at room temperature for 4 hours and 30 minutes. The solvent was removed under reduced pressure,diisopropyl ether was added to the obtained residue, and solid matter was filtrated to give 2-((biphenyl-4-yl)amino)-4-phenethylbenzoic acid 27 mg of a yellow solid.

Workup

  1. customThe solvent was removed under reduced pressure,diisopropyl ether
  2. additionwas added to the obtained residue, and solid matter
  3. filtrationwas filtrated

Sources & evidence

ORD record
ord-feb208daae10435883fa1018dfd8040f
Source dataset
uspto-grants-2012_12
Patent number
US08327467B2

Reaction notes

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