反应详情

Ammonium formate (964 mg) and [1,1′-bis(diphenylphosphino)-ferrocene]dichloropalladium(II)/dichloromethane complex (208 mg) were added to a tetrahydrofuran (10 mL) solution of 6′-[2-allyl-6-(methylthio)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2H-1,2′-bipyridin-2-one (1 g), and heated overnight under reflux. The reaction liquid was cooled to room temperature, then diluted with chloroform, and washed with water and saturated saline water in order. The organic layer was dried with anhydrous magnesium sulfate. The insoluble matter was dissolved, and then the solvent was evaporated away to give crude 6′-[6-(methylthio)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2H-1,2′-bipyridin-2-one.

1. temperatureheated overnight
2. temperatureunder reflux
3. customThe reaction liquid
4. washwashed with water and saturated saline water in order
5. dry with materialThe organic layer was dried with anhydrous magnesium sulfate
6. dissolutionThe insoluble matter was dissolved
7. customthe solvent was evaporated away