Water → 2-Bromo-N-(6-trifluoromethyl-pyridazin-3-yl)-acetamide

HRID 2192302Notes

Reaction equation

HRID 2192302 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[N:8]=[N:7][C:6]([NH2:9])=[CH:5][CH:4]=1.C(=O)([O-])[O-].[K+].[K+].[Br:18][CH2:19][C:20](Br)=[O:21].O>ClCCl>[Br:18][CH2:19][C:20]([NH:9][C:6]1[N:7]=[N:8][C:3]([C:2]([F:1])([F:10])[F:11])=[CH:4][CH:5]=1)=[O:21]

Participants

6

Reactant 4

HCID 962Water2×HCID 11430Potassium CarbonateHCID 61147Bromoacetyl bromideHCID 598058596-(Trifluoromethyl)pyridazin-3-amine

Product 1

HCID 670277332-Bromo-N-(6-trifluoromethyl-pyridazin-3-yl)-acetamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

6-Trifluoromethyl-pyridazin-3-ylamine (0.042 g) (prepared by a procedure similar to that described in WO2007048779) was dissolved in dichloromethane (40 mL) and stirred with potassium carbonate (0.214 g). 2-Bromoacetyl bromide (0.12 mL) was added and stirring continued for 1.5 hours. Water (0.24 mL) was added and the reaction mixture was stirred for 1.5 hours after which water (40 mL) was added and the reaction mixture stirred for a further 1.5 hours. The dichloromethane was separated, dried (MgSO4) and evaporated to afford the sub-titled compound as a white solid (0.053 g).

Workup

  1. additionwas added
  2. stirringthe reaction mixture stirred for a further 1.5 hours
  3. customThe dichloromethane was separated
  4. dry with materialdried (MgSO4)
  5. customevaporated

Sources & evidence

ORD record
ord-79a9d785de3d43c5ac5f844ce979c38f
Source dataset
uspto-grants-2012_12
Patent number
US08329729B2

Reaction notes

Loading…