反应详情

To a mixture of 5-methyl-pyrazin-2-ylamine and cesium carbonate (11.2 g) dissolved in dry DMF (30 mL) was added by dropwise addition bromoacetylbromide (2.89 g) and the mixture stirred at rt for 2 hours. Water (200 mL) was added and the mixture extracted with ethyl acetate (2×100 mL) and dried over magnesium sulfate. Concentration of the extract to ˜50 mL and addition of isohexane (100 mL) gave the sub-titled compound as a solid (1.64 g).

1. extractionthe mixture extracted with ethyl acetate (2×100 mL)
2. dry with materialdried over magnesium sulfate
3. extractionConcentration of the extract to ˜50 mL and addition of isohexane (100 mL)