Potassium Carbonate → 2-bromo-N-(pyrazin-2-yl)acetamide

HRID 2192319Notes

Reaction equation

HRID 2192319 reaction equation
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[NH2:7].C(=O)([O-])[O-].[K+].[K+].[Br:14][CH2:15][C:16](Br)=[O:17]>ClCCl>[Br:14][CH2:15][C:16]([NH:7][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][N:1]=1)=[O:17]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 61147Bromoacetyl bromideHCID 78747Aminopyrazine

Product 1

HCID 445426692-bromo-N-(pyrazin-2-yl)acetamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred suspension of pyrazin-2-ylamine (1.87 g) and potassium carbonate (8.19 g) in dichloromethane (25 mL) was added by dropwise addition 2-bromoacetyl bromide (1.72 mL). The reaction mixture was stirred overnight and then washed with water (2×50 mL). The organic phase was separated, dried with magnesium sulfate and evaporated to yield the sub-titled compound (0.70 g).

Workup

  1. washwashed with water (2×50 mL)
  2. customThe organic phase was separated
  3. dry with materialdried with magnesium sulfate
  4. customevaporated

Sources & evidence

ORD record
ord-27e396e24d99440181389aa40ad5aa06
Source dataset
uspto-grants-2012_12
Patent number
US08329729B2

Reaction notes

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